Michael Hothorn
Labs 1078 - 1081
+41 22 379 30 13
E-mail
Structural Plant Biology
Research Interests
- Plant membrane signal transduction
- Inositol pyrophosphate metabolism and signaling
Key Publications
Raia P., Lee K., Bartsch S.M., Rico-Resendiz F., Portugal-Calisto D., Vadas O., Panse V.G., Fiedler D. & Hothorn M.:
A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis.
Nat Commun 2025, 16(1):1753. PMID: 39966396. DOI: 10.1038/s41467-025-56937-0.
Laurent F., Bartsch S.M., Shukla A., Rico-Resendiz F., Couto D., Fuchs C., Nicolet J., Loubéry S., Jessen H.J., Fiedler D. & Hothorn M.:
Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development.
PLoS Genet 2024, 20(11):e1011468. PMID: 39531477. DOI: 10.1371/journal.pgen.1011468.
Ried M.K., Wild R., Zhu J., Pipercevic J., Sturm K., Broger L., Harmel R.K., Abriata L.A., Hothorn L.A., Fiedler D., Hiller S. & Hothorn M.:
Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis.
Nat Commun 2021, 12(1):384. PMID: 33452263. DOI: 10.1038/s41467-020-20681-4.
Hohmann U., Ramakrishna P., Wang K., Lorenzo-Orts L., Nicolet J., Henschen A., Barberon M., Bayer M. & Hothorn M.:
Constitutive Activation of Leucine-Rich Repeat Receptor Kinase Signaling Pathways by BAK1-INTERACTING RECEPTOR-LIKE KINASE3 Chimera.
Plant Cell 2020, 32(10):3311-3323. PMID: 32796127. DOI: 10.1105/tpc.20.00138.
Okuda S., Fujita S., Moretti A., Hohmann U., Doblas V.G., Ma Y., Pfister A., Brandt B., Geldner N. & Hothorn M.:
Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.
Proc Natl Acad Sci U S A 2020, 117(5):2693-2703. PMID: 31964818. DOI: 10.1073/pnas.1911553117.
Further Reading
Lorenzo-Orts L., Couto D. & Hothorn M.:
Identity and functions of inorganic and inositol polyphosphates in plants.
New Phytol 2020, 225(2):637-652. PMID: 31423587. DOI: 10.1111/nph.16129.
Hohmann U., Lau K. & Hothorn M.:
The Structural Basis of Ligand Perception and Signal Activation by Receptor Kinases.
Annu Rev Plant Biol 2017, 68:109-137. PMID: 28125280. DOI: 10.1146/annurev-arplant-042916-040957.