Karl Perron
Labs 0057 - 0077
+41 22 379 31 27
E-mail
Molecular Bacteriology
Research Interests
In our laboratory we are studying the mechanism of cross-resistance between heavy metals and antibiotics. Molecular bacteriology and biochemistry methods are used to monitor the effect of Zn, Cd, Co and Cu on the bacterium Pseudomonas aeruginosa. Our group interacts strongly with the section of pharmaceutical sciences and the medical faculty for both teaching activities and research. We are also interested in problems related to wound infections. The laboratory offers various services, expertise and microbiological analysis to the community, particularly in the context of the search for new antimicrobial molecules (see PAM). The team manages various communication missions and services to schools and the general public in the field of life sciences (see BiOutils; services to the city).
Key Publications
Gonzalez MR, Ducret V, Leoni S, Fleuchot B, Jafari P, Applegate LA, Raffoul W, Que Y-A, Perron K. Transcriptome Analysis of Pseudomonas aeruginosa Cultured in Human Burn Wound Exudates. Front. Cell. Infect. Microbiol.,2018.
Ducret V, Gonzalez MR, Scrignari T, Perron K. OprD repression upon metal treatment requires the RNA chaperone Hfq in Pseudomonas aeruginosa. Genes. 3;7(10), 2016.
Dieppois G, Ducret V, Caille O, Perron K. The Transcriptional Regulator CzcR Modulates Antibiotic Resistance and Quorum Sensing in Pseudomonas aeruginosa. PLoS ONE. 2012;7(5):e38148. Epub 2012 May 29.
Further Reading
Gonzalez MR, Ducret V, Leoni S, Perron K. Pseudomonas aeruginosa zinc homeostasis: Key issues for an opportunistic pathogen.Biochim Biophys Acta. 2018.
Caine M, Zuchuat S, Weber A, Ducret V, Linder P, Perron K. BiOutils: an interface to connect university laboratories with microbiology classes in schools. FEMS Microbiol Lett. Sept. 2015.